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Fentanyl Patches Online, Patients can Buy Fentanyl Patches Online, Fentanyl patches can already be prescribed on the Pharmaceutical Benefits Scheme for chronic severe cancer pain. The listing has changed from August 2006 to include chronic non-cancer pain. Listing was approved on a cost-minimisation basis, that is, transdermal fentanyl was no less effective than oral sustained-release morphine, and for similar cost.The Pharmaceutical Benefits Advisory Committee recommended that transdermal fentanyl should not be initiated in opioid-naïve patients with non-cancer pain, because of a high risk of adverse events.
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secondly, On first application it usually takes 24–72 hours for serum concentrations of fentanyl to reach a peak, so it may not be until the second patch has been applied that a steady-state concentration is reached. Break-through analgesia may be required initially. Wean other analgesics slowly after the first patch.2
Fentanyl matrix patches are available in several dosages expressed as the number of micrograms delivered per hour — 12, 25, 50, 75 and 100 micrograms per hour. The older reservoir patches were labelled according to the amount of fentanyl contained in the patch (2.5 mg, 5 mg, 7.5 mg, 10 mg); however, because the matrix patches contain more fentanyl to achieve the same hourly dose, delivery rate rather than total content is now used, to avoid confusion.
If required, titrate the dosage using 12 or 25 microgram-per-hour patches at 72-hour intervals (not less).8 Estimate needs from doses of breakthrough analgesia required over several days, but exclude the first patch from this assessment
Subsequently The possible side effects of DURAGESIC;
constipation, nausea, sleepiness, vomiting, tiredness, headache, dizziness, abdominal pain, itching, redness, or rash where the patch is applied. Call your healthcare provider if you have any of these symptoms and they are severe.
- Mild to Moderate Hepatic and Renal Impairment: Initiate treatment with one half the usual starting dose, titrate slowly, and monitor for signs of respiratory and central nervous system depression.
Do not abruptly discontinue Duragesic in a physically-dependent patient
- Deaths have occurred with use of fentanyl patches in opioid-naïve patients. Do not use in opioid-naïve patients with non-cancer pain and consider the ratio of benefits to harm before prescribing for cancer pain.
- Elderly patients, in whom there is reduced clearance and a prolonged half-life, may be more sensitive to the effects of fentanyl.
- Do not cut or divide patches.
- Be aware that increased body heat (e.g. fever, humid climate) and direct heat (e.g. from electric blankets, saunas) may increase the rate of absorption.
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